NOTA-AE105

Names

[ CAS No. ]:
1820563-84-5

[ Name ]:
NOTA-AE105

Biological Activity

[Description]:

NOTA-AE105 is an PET ligand of urokinase-type plasminogen activator receptor (uPAR), which can be radiolabeled by 64Cu and 68Ga. 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 shows high image contrast, resulting in clear tumor delineation[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Urokinase-type plasminogen activator receptor (uPAR)[2]

[References]

[1]. Risør LM, et al. Prognostic Value of Urokinase-Type Plasminogen Activator Receptor PET/CT in Head and Neck Squamous Cell Carcinomas and Comparison with 18F-FDG PET/CT: A Single-Center Prospective Study. J Nucl Med. 2022 Aug;63(8):1169-1176.

[2]. Persson M, et al. uPAR is a promising new imaging biomarker in glioblastoma[J]. Journal of Nuclear Medicine, 2015.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₂H₁₀₂N₁₆O₂₀

[ Molecular Weight ]:
1511.68

Related Compounds

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