Dichlorophenyl-ABA

Names

[ Name ]:
Dichlorophenyl-ABA

[Synonym ]:
Dichlorophenyl-ABA
benzoic acid,2-[(3,5-dichlorophenyl)amino]
2-[(3,5-Dichlorophenyl)amino]benzoic acid
N-(3,5-dichloro-phenyl)-anthranilic acid
2-[(3,5-dichlorophenyl)amino]benzoic acid
N-(3,5-Dichlorphenyl)-anthranilsaeure

Biological Activity

[Description]:

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

Transthyretin (TTR) amyloid fibril formation

[In Vitro]

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are[1]. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity[1].

[References]

[1]. Cardoso I, et al. Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design. Biochem J. 2007 Nov 15;408(1):131-8.

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Boiling Point ]:
420.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₉Cl₂NO₂

[ Molecular Weight ]:
282.12200

[ Flash Point ]:
208.3ºC

[ Exact Mass ]:
281.00100

[ PSA ]:
49.33000

[ LogP ]:
4.50820

[ Vapour Pressure ]:
7.85E-08mmHg at 25°C

[ Index of Refraction ]:
1.677

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%