5-Chlorouracil
Names
[ CAS No. ]:
1820-81-1
[ Name ]:
5-Chlorouracil
[Synonym ]:
5-Chloropyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione,5-chloro
5-Chlorouracil
5-chloro-2,4-dioxopyrimidine
5-chloro-1H-pyrimidine-2,4-dione
4-chlorouracil
5-Chloro-2,4(1H,3H)-pyrimidinedione
EINECS 217-339-7
5-chloro-uracil
Uracil,5-chloro
2,4(1H,3H)-Pyrimidinedione, 5-chloro-
5-Chloro-2,4-dihydroxypyrimidine
MFCD00006019
5-Chloropyrimidine-2,4-diol
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C4H3ClN2O2
[ Molecular Weight ]:
146.53
[ Flash Point ]:
203.9ºC
[ Exact Mass ]:
145.988312
[ PSA ]:
65.72000
[ LogP ]:
-0.52
[ Vapour Pressure ]:
1.98E-07mmHg at 25°C
[ Index of Refraction ]:
1.587
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YQ9410000
- CHEMICAL NAME :
- Uracil, 5-chloro-
- CAS REGISTRY NUMBER :
- 1820-81-1
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C4-H3-Cl-N2-O2
- MOLECULAR WEIGHT :
- 146.54
- WISWESSER LINE NOTATION :
- T6MVMVJ FG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 50 mg/L/1H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 38,371,1976
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
YQ9410000
[ HS Code ]:
29335995
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933599090
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Chem. Phys. 120 , 704-709, (2004)
Low energy electron impact to the isomers 6-chlorouracil (6-ClU) and 5-chlorouracil (5-ClU) yields a variety of negative ion fragments with surprisingly high cross sections. These ions are dominantly ...
Polymerase incorporation and miscoding properties of 5-chlorouracil.Chem. Res. Toxicol. 23 , 740-748, (2010)
Inflammation-mediated hypochlorous acid (HOCl) can damage DNA, DNA precursors, and other biological molecules, thereby producing an array of damage products such as 5-chlorouracil (ClU). In this study...
Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages.J. Biol. Chem. 281(6) , 3096-104, (2006)
Somatic mutations induced by oxidative damage of DNA might play important roles in atherogenesis. However, the underlying mechanisms remain poorly understood. Myeloperoxidase, a heme protein expressed...