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Ubiquitination-IN-1

Names

[ CAS No. ]:
1819330-15-8

[ Name ]:
Ubiquitination-IN-1

Biological Activity

[Description]:

Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 can be used to treat disease by blocking the degradation of tumor suppressors[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[In Vitro]

Ubiquitination-IN-1 inhibits A549 and HT1080 cells with IC50s of 0.91 and 0.4 μM, respectively[1].

[References]

[1]. David Carroll, et al.Quinoline derivatives useful as ubiquitination inhibitors. WO2016025779A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14F3N3O2S

[ Molecular Weight ]:
429.41

Related Compounds