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InteriotherinA

Names

[ CAS No. ]:
181701-06-4

[ Name ]:
InteriotherinA

[Synonym ]:
Interiotherin A

Biological Activity

[Description]:

Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Research Areas >> Metabolic Disease

[In Vitro]

Interiotherin A (Compounds 1) (0.8-100µg/mL; 4 hours) inhibits HIV replication with EC50 values of 3.1 µg/mL[1]. Cell Cytotoxicity Assay[1] Cell Line: T cell line: HS1 Concentration: 100 µg/mL, 20 µg/mL, 4 µg/mL, and 0.8 µg/mL Incubation Time: 4 hours Result: Exhibited anti-HIV activity.

[References]

[1]. Chen DF, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996 Nov;59(11):1066-8.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
643.3ºC at 760 mmHg

[ Melting Point ]:
153-154 °C

[ Molecular Formula ]:
C29H28O8

[ Molecular Weight ]:
504.52800

[ Flash Point ]:
273.8ºC

[ Exact Mass ]:
504.17800

[ PSA ]:
81.68000

[ LogP ]:
5.55460

[ Vapour Pressure ]:
1.93E-16mmHg at 25°C

[ Index of Refraction ]:
1.64


Related Compounds

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