diethyl 5-(hydroxymethyl)benzene-1,3-dicarboxylate
Names
[ CAS No. ]:
181425-91-2
[ Name ]:
diethyl 5-(hydroxymethyl)benzene-1,3-dicarboxylate
[Synonym ]:
3,5-bis(ethoxycarbonyl)-benzyl alcohol
MFCD00239424
5-(hydroxymethyl) isophtalic acid diethyl ester
5-hydroxymethylisophthalic acid diethyl ester
3,5-diethoxycarbonylbenzyl alcohol
diethyl 5-(hydroxymethyl)-isophthalate
Chemical & Physical Properties
[ Density]:
1.189g/cm3
[ Boiling Point ]:
398.6ºC at 760 mmHg
[ Melting Point ]:
82-85ºC(lit.)
[ Molecular Formula ]:
C13H16O5
[ Molecular Weight ]:
252.26300
[ Flash Point ]:
148.7ºC
[ Exact Mass ]:
252.10000
[ PSA ]:
72.83000
[ LogP ]:
1.53230
[ Vapour Pressure ]:
4.54E-07mmHg at 25°C
[ Index of Refraction ]:
1.53
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S23
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Nucleic Acids Res. 30(21) , 4793-802, (2002)
We report the synthesis of new phosphoramidite building blocks and their use for the modification of oligonucleotides with hydrazides. The reaction of these hydrazide oligonucleotides with active este...
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.J. Med. Chem. 52 , 3969-81, (2009)
Protein kinase C (PKC) is a widely studied molecular target for the treatment of cancer and other diseases. We have approached the issue of modifying PKC function by targeting the C1 domain in the reg...
Hydrophobic derivatives of 5-(hydroxymethyl) isophthalic acid that selectively induce apoptosis in leukemia cells but not in fibroblasts. Galkin A, et al.Drug Dev. Res. 69(4) , 185-95, (2008)