(1S,2S,3R)-DT-061

Names

[ Name ]:
(1S,2S,3R)-DT-061

Biological Activity

[Description]:

(1S,2S,3R)-DT-061 is an enantiomer of DT-061. DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Kauko O, et al. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₃F₃N₂O₅S

[ Molecular Weight ]:
520.52

Related Compounds

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