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Biotin-PEG6-Maleimide

Names

[ CAS No. ]:
1808990-66-0

[ Name ]:
Biotin-PEG6-Maleimide

[Synonym ]:
N-[24-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-22-oxo-3,6,9,12,15,18-hexaoxa-21-azatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[24-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-22-oxo-3,6,9,12,15,18-hexaoxa-21-azatetracos-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)-
MFCD28015769

Biological Activity

[Description]:

Biotin-PEG6-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
944.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C31H51N5O11S

[ Molecular Weight ]:
701.828

[ Flash Point ]:
525.1±34.3 °C

[ Exact Mass ]:
701.330566

[ LogP ]:
-3.19

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.528

[ Storage condition ]:
-20°C

Related Compounds