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Fluorescein-PEG3-Amine

Names

[ CAS No. ]:
1807539-04-3

[ Name ]:
Fluorescein-PEG3-Amine

[Synonym ]:
Benzoic acid, 5-[(13-amino-1-thioxo-5,8,11-trioxa-2-azatridec-1-yl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
5-{[(2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethyl)carbamothioyl]amino}-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
MFCD23726633

Biological Activity

[Description]:

Fluorescein-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
827.9±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H31N3O8S

[ Molecular Weight ]:
581.637

[ Flash Point ]:
454.5±37.1 °C

[ Exact Mass ]:
581.183167

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds