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Mal-PEG5-NHS ester

Names

[ CAS No. ]:
1807537-42-3

[ Name ]:
Mal-PEG5-NHS ester

[Synonym ]:
1-{18-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-18-oxo-3,6,9,12,15-pentaoxaoctadec-1-yl}-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-[18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxo-3,6,9,12,15-pentaoxaoctadec-1-yl]-

Biological Activity

[Description]:

Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
608.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H30N2O11

[ Molecular Weight ]:
486.470

[ Flash Point ]:
321.7±34.3 °C

[ Exact Mass ]:
486.184967

[ LogP ]:
-3.32

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8°C

Related Compounds