BnO-PEG5-Boc

Names

[ Name ]:
BnO-PEG5-Boc

[Synonym ]:
MFCD28142466
2,5,8,11,14,17-Hexaoxanonadecan-19-oic acid, 1-phenyl-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-oate

Biological Activity

[Description]:

BnO-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
507.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₈O₈

[ Molecular Weight ]:
442.543

[ Flash Point ]:
214.4±28.8 °C

[ Exact Mass ]:
442.256653

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.483

BnO-PEG5-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds