Frunexian

Names

[ Name ]:
Frunexian

Biological Activity

[Description]:

Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[Target]

IC50: 7 nM (human Factor XIa)[1]

[References]

[1]. Pollack CV Jr, et al. EP-7041, a Factor XIa Inhibitor as a Potential Antithrombotic Strategy in Extracorporeal Membrane Oxygenation: A Brief Report. Crit Care Explor. 2020 Sep 15;2(9):e0196.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₆N₄O₄

[ Molecular Weight ]:
374.43

Related Compounds

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