1803270-60-1

1803270-60-1 structure

Name: Frunexian
Chemical Name: Frunexian
CAS Number: 1803270-60-1
Molecular Formula: C₁₉H₂₆N₄O₄
Molecular Weight: 374.43
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2023-09-29 14:07:44
Modify Date: 2024-01-15 15:49:34
Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research[1].

Name	Frunexian

Description	Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
Target	IC50: 7 nM (human Factor XIa)[1]
References	[1]. Pollack CV Jr, et al. EP-7041, a Factor XIa Inhibitor as a Potential Antithrombotic Strategy in Extracorporeal Membrane Oxygenation: A Brief Report. Crit Care Explor. 2020 Sep 15;2(9):e0196.

Molecular Formula	C₁₉H₂₆N₄O₄
Molecular Weight	374.43