L-Phenylalanine-13C6

Names

[ Name ]:
L-Phenylalanine-13C6

[Synonym ]:
L-(1,2,3,4,5,6-13C6)Phenylalanine
L-PHENYL-13C6-ALANINE
L-Phenylalanine-1,2,3,4,5,6-13C6
(2S)-2-Amino-3-phenylpropanoic Acid-13C6
MFCD00144663

Biological Activity

[Description]:

L-Phenylalanine-13C6 ((S)-2-Amino-3-phenylpropionic acid-13C6) is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Melting Point ]:
239-242° C

[ Molecular Formula ]:
C₃₁₃C₆H₁₁NO₂

[ Molecular Weight ]:
171.15

[ Exact Mass ]:
171.099106

[ Index of Refraction ]:
1.576

Related Compounds

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