TNO155

Names

[ Name ]:
TNO155

[Synonym ]:
MFCD32693919

Biological Activity

[Description]:

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

IC50: 0.011 µM (SHP2)[1]

[In Vitro]

TNO155 shows an IC50 of 0.008 µM in KYSE520 pERK assay and shows an IC50 of 0.100 µM in KYSE520 5-day cell proliferation assay. The off-target IC50 values are 18 µM, 6.9 µM, and 11 µM for Cav1.2, VMAT, and SST3, respectively[1].

[In Vivo]

The oral bioavailability in mouse, rat and money are 78%, 86%, and 60%, respectively[1].

[References]

[1]. TNO155: SHP2 inhibitor

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₄ClN₇OS

[ Molecular Weight ]:
421.95

Related Compounds

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