QX-77

Names

[ CAS No. ]:
1798331-92-6

[ Name ]:
QX-77

Biological Activity

[Description]:

QX77 is a chaperone-mediated autophagy (CMA) activator.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

[Target]

CMA[1]

[In Vitro]

Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane[1].

[Cell Assay]

Mouse embryo fibroblasts are preincubated with QX77 or vehicle (DMSO) 48 h before the addition of tert-butyl hydroperoxide. After an overnight incubation, cell viability is determined by a modified version of the MTT assay[1].

[References]

[1]. Zhang J, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₃ClN₂O₂

[ Molecular Weight ]:
300.74

[ Storage condition ]:
2-8℃

Related Compounds

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