AR 420626

Names

[ Name ]:
AR 420626

[Synonym ]:
3-Quinolinecarboxamide, N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-
AR420626
N-(2,5-Dichlorophenyl)-4-(2-furyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxamide
N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxamide
AR 420626
MFCD28987470

Biological Activity

[Description]:

AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM. AR420626 inhibits nicotine and serotonin-induced changes in motility of isolated muscle strips from rat colon and suppresses serotonin-induced fecal output in rats[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Kaji I, et al. Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol Motil. 2018 Jan;30(1):10.1111/nmo.13157.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
619.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₈Cl₂N₂O₃

[ Molecular Weight ]:
417.285

[ Flash Point ]:
328.3±31.5 °C

[ Exact Mass ]:
416.069458

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.653

Related Compounds

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