DiaPep277

Names

[ Name ]:
DiaPep277

Biological Activity

[Description]:

DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vivo]

DiaPep277 (50 μg; i.p.; single dosage) causes strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses[2]. Animal Model: Female NOD mice (diabetes model)[2] Dosage: 50 μg Administration: i.p.; single dosage Result: Caused strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀₆H₁₈₀N₂₈O₃₄

[ Molecular Weight ]:
2390.73

Related Compounds

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