HSP70/SIRT2-IN-2

Names

[ Name ]:
HSP70/SIRT2-IN-2

Biological Activity

[Description]:

HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[References]

[1]. Elena Abbotto, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel). 2023 Sep 18;16(9):1316.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₃N₃S₃

[ Molecular Weight ]:
355.50

Related Compounds

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