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CPCCOEt

Names

[ CAS No. ]:
179067-99-3

[ Name ]:
CPCCOEt

[Synonym ]:
CPCCOET
Astemizole

Biological Activity

[Description]:

CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of metabotropic glutamate receptor 1b (mGluR1b)[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGluR1b


[References]

[1]. Litschig S, et al. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol Pharmacol. 1999 Mar;55(3):453-61. 

[2]. Hermans E,et al. Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor. Neuropharmacology. 1998 Dec;37(12):1645-7. 

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
397.8ºC at 760mmHg

[ Molecular Formula ]:
C13H13NO4

[ Molecular Weight ]:
247.24700

[ Flash Point ]:
194.4ºC

[ Exact Mass ]:
247.08400

[ PSA ]:
68.12000

[ LogP ]:
1.57910

[ Vapour Pressure ]:
4.82E-07mmHg at 25°C

[ Index of Refraction ]:
1.644

Safety Information

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds