(3-Carboxypropyl)(triphenyl)phosphonium bromide

[ Melting Point ]:
244-247 °C(lit.)

[ Molecular Formula ]:
C₂₂H₂₂BrO₂P

[ Molecular Weight ]:
429.287

[ Exact Mass ]:
428.054077

[ PSA ]:
50.89000

[ LogP ]:
0.84930

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[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor

DownStream

Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435/DOX cells.

Mol. Pharm. 11(8) , 2640-9, (2014)

In this study, doxorubicin (DOX) was conjugated to a lipophilic triphenylphosphonium (TPP) that is selectively taken up by the mitochondrial membrane of cells. This new derivative of DOX, i.e., TPP-DO...

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