MRT67307 dihydrochloride

Names

[ Name ]:
MRT67307 dihydrochloride

Biological Activity

[Description]:

MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> ULK

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

[References]

[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.

[2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₈Cl₂N₆O₂

[ Molecular Weight ]:
537.52

Related Compounds

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