1781882-89-0

1781882-89-0 structure

Name: MRT67307 dihydrochloride
Chemical Name: MRT67307 dihydrochloride
CAS Number: 1781882-89-0
Molecular Formula: C₂₆H₃₈Cl₂N₆O₂
Molecular Weight: 537.52
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2023-09-17 08:27:23
Modify Date: 2025-08-27 18:17:51
MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].

Name	MRT67307 dihydrochloride

Description	MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells[2].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Cancer Signaling Pathways >> Autophagy >> ULK Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology
References	[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. [2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.

Molecular Formula	C₂₆H₃₈Cl₂N₆O₂
Molecular Weight	537.52