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Calcicludine

Names

[ CAS No. ]:
178036-64-1

[ Name ]:
Calcicludine

Biological Activity

[Description]:

Calcicludine is a protein toxin from the venom of the green mamba Dendroaspis angusticeps that inhibits high-voltage-activated calcium channel, especially L-type calcium channel with the IC50 of 88 nM. Calcicludine has role in excitatory synaptic transmission[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Neurological Disease

[Target]

L-type calcium channel:88 nM (IC50)


[References]

[1]. H Schweitz, et al. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):878-82.  

[2]. S C Stotz, et al. Block of Voltage-dependent Calcium Channel by the Green Mamba Toxin Calcicludine. J Membr Biol. 2000 Mar 15;174(2):157-65.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds