Sauchinone

Names

[ Name ]:
Sauchinone

[Synonym ]:
(5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one
Sauchinone
5H-Benzo[kl][1,3]dioxolo[4,5-b]-1,3-dioxolo[4,5-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)-

Biological Activity

[Description]:

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

p65

I-kappaBalpha

[In Vitro]

Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells[1]. Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively[1].

[References]

[1]. Lee AK, et al. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol. 2003 May;139(1):11-20.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
498.1±45.0 °C at 760 mmHg

[ Melting Point ]:
224-226℃

[ Molecular Formula ]:
C₂₀H₂₀O₆

[ Molecular Weight ]:
356.369

[ Flash Point ]:
220.3±28.8 °C

[ Exact Mass ]:
356.125977

[ PSA ]:
63.22000

[ LogP ]:
3.81

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.643

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble5mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29329990

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.