6bK

Names

[ Name ]:
6bK

Biological Activity

[Description]:

6bK is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. 6bK increases circulating insulin in high-fat-fed mice. Acute administration of 6bK enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

IC50: 50 nM (IDE)[1]

[References]

[1]. Costes S, Butler PC. Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes?. Cell Metab. 2014;20(2):201-203.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₃H₅₆F₃N₇O₉

[ Molecular Weight ]:
871.94

Related Compounds

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