Olinone

Names

[ Name ]:
Olinone

[Synonym ]:
N-[4-(1-Oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide
Acetamide, N-[4-(1,2,3,4-tetrahydro-1-oxo-5H-pyrido[4,3-b]indol-5-yl)butyl]-
MFCD28976195

Biological Activity

[Description]:

Olinone is a selective BRD4 BrD1 inhibitor[1]. Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation[2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[References]

[1]. Rodríguez Y, et al. In silico design and molecular basis for the selectivity of Olinone toward the first over the second bromodomain of BRD4. Proteins. 2020 Mar;88(3):414-430.

[2]. Gacias M, et al. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol. 2014 Jul 17;21(7):841-854.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
675.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₁N₃O₂

[ Molecular Weight ]:
299.37

[ Flash Point ]:
362.4±31.5 °C

[ Exact Mass ]:
299.163391

[ LogP ]:
0.62

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.643

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
T+

Related Compounds

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