O4I1

Names

[ Name ]:
O4I1

[Synonym ]:
2-[4-[(4-Methoxyphenyl)methoxy]phenyl]-acetonitrile
4-(4-methoxybenzyloxy)benzylnitrile
Benzeneacetonitrile, 4-[(4-methoxyphenyl)methoxy]-
{4-[(4-Methoxybenzyl)oxy]phenyl}acetonitrile
O4I1
2-(4-((4-Methoxybenzyl)oxy)phenyl)acetonitrile
2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE
O4I-1

Biological Activity

[Description]:

O4I1 is as a potent Oct3/4 inducer.Target: Oct3/4O4I1 enhances Oct3/4 gene expression, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. O4I1 activates Oct3/4 at the transcriptional and translational levels in diverse human cell lines. O4I1 promotes Oct3/4 expression in untransfected HEK293 cells quantified by qRT-PCR after 72 h of treatment. O4I1 is sufficient to enhance Oct3/4 overexpression 2-fold and 3-fold after 48 and 72 h of treatment, respectively.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Oct3/4

Research Areas >> Others

[References]

[1]. Cheng X, et al. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58(12):4976-4983.

[2]. Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103.

[Related Small Molecules]

OAC-2 | O4I2 | OAC1

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
424.5±30.0 °C at 760 mmHg

[ Melting Point ]:
140ºC

[ Molecular Formula ]:
C₁₆H₁₅NO₂

[ Molecular Weight ]:
253.296

[ Flash Point ]:
154.8±17.8 °C

[ Exact Mass ]:
253.110275

[ PSA ]:
42.25000

[ LogP ]:
2.93

[ Appearance of Characters ]:
light yellow solid

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.570

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36/37

[ HS Code ]:
2926909090

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%