(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

Names

[ Name ]:
(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

[Synonym ]:
(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione

Biological Activity

[Description]:

Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188[1]. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans[2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

[Target]

IC50: 6 μM (ACAT, acyl-CoA:cholesterol acyltransferase)[1]

[References]

[1]. K Hasumi, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo).1993 Dec;46(12):1782-7.

[2]. Robin K Pettit, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₉NO₃

[ Molecular Weight ]:
261.31600

[ Exact Mass ]:
261.13600

[ PSA ]:
46.61000

[ LogP ]:
1.57540

Related Compounds

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