172721-98-1

172721-98-1 structure

Name: (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione
Chemical Name: (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione
CAS Number: 172721-98-1
Molecular Formula: C₁₅H₁₉NO₃
Molecular Weight: 261.31600
Catalog: Research Areas Cancer
Create Date: 2018-05-31 08:13:54
Modify Date: 2024-02-05 19:12:44
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188[1]. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans[2].

Name	(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione
Synonyms	(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione

Description	Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188[1]. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
Target	IC50: 6 μM (ACAT, acyl-CoA:cholesterol acyltransferase)[1]
References	[1]. K Hasumi, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo).1993 Dec;46(12):1782-7. [2]. Robin K Pettit, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-1.