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Guvacoline Hydrobromide

Names

[ CAS No. ]:
17210-51-4

[ Name ]:
Guvacoline Hydrobromide

[Synonym ]:
methyl 1,2,3,6-tetrahydropyridine-5-carboxylate,hydrobromide

Biological Activity

[Description]:

Guvacoline hydrobromide, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal mAChR[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> mAChR

[References]

[1]. Jiao Wu, et al. Tissue-specific and maturity-dependent distribution of pyridine alkaloids in Areca triandra. J Plant Res. 2019 Jul;132(4):531-540.

[2]. M Wolf-Pflugmann, et al. Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. Arzneimittelforschung. 1989 May;39(5):539-44.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₂BrNO₂

[ Molecular Weight ]:
222.08

[ Exact Mass ]:
221.00500

[ PSA ]:
38.33000

[ LogP ]:
1.36600

Precursor & DownStream

Precursor

DownStream

Related Compounds