4-Nitrobenzoic acid-d4

Names

[ Name ]:
4-Nitrobenzoic acid-d4

[Synonym ]:
4-O2N-C6D4-COOH
4-nitro<2,3,5,6-2H4>benzoic acid
4-Nitro-naphthalene-1-carbaldehyde
1-Naphthalenecarboxaldehyde,4-nitro

Biological Activity

[Description]:

4-Nitrobenzoic acid-d4 is the deuterium labeled 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate (Vonoprazan Impurity）[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇HD₄NO₄

[ Molecular Weight ]:
171.14

[ Exact Mass ]:
171.04700

[ PSA ]:
83.12000

[ LogP ]:
1.81620

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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