6-epi-Tadalafil

Names

[ Name ]:
6-epi-Tadalafil

[Synonym ]:
Tadalafil 6S,12ar diastereomer
epi-tadafil
UNII-MGY23Z94HY
6-epi-Tadalafil
Tadalafil Impurity 11

Biological Activity

[Description]:

cis-ent-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Metabolic Disease

[References]

[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46(21):4533-42.

Chemical & Physical Properties

[ Density]:
1.51±0.1 g/cm3 (20 ºC 760 Torr)

[ Melting Point ]:
290-292 ºC

[ Molecular Formula ]:
C₂₂H₁₉N₃O₄

[ Molecular Weight ]:
389.40

[ Exact Mass ]:
389.13800

[ PSA ]:
74.87000

[ LogP ]:
2.08710

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Insuluble (8.6E-3 g/L) (25 ºC)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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