Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one,2',3',8',8'a-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-

Names

[ Name ]:
Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one,2',3',8',8'a-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-

[Synonym ]:
Unii-ke7J8A65p6
Glaziovina [inn-spanish]
N-Methyl-crotsparin
(+-)-Glaziovin
Glaziovinum
Glaziovina
Glaziovinum [inn-latin]
N-methylcrotsparine

Biological Activity

[Description]:

Glaziovine, a proaporphine alkaloid, has anxiolytic activity. Glaziovine can be used for neuropharmacological research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. F.D. Bellamy, et al. Synthesis of derivatives structurally related to glaziovine. Tetrahedron. Volume 39, Issue 17, 1983, Pages 2803-2806.

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
470.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₁₉NO₃

[ Molecular Weight ]:
297.34800

[ Flash Point ]:
238.5ºC

[ Exact Mass ]:
297.13600

[ PSA ]:
49.77000

[ LogP ]:
2.20430

[ Vapour Pressure ]:
1.74E-09mmHg at 25°C

[ Index of Refraction ]:
1.668

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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