EGLU

Names

[ Name ]:
EGLU

[Synonym ]:
EGLU
Tocris-0971
L-Glutamic acid,2-ethyl

Biological Activity

[Description]:

EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[In Vitro]

EGLU (200 μM) selectively antagonizes (lS,3S)-ACPD-induced depressions of the monosynaptic component of the DRVRP, displaying little or no antagonist activity versus L-AP6 induced depressions or on the DRVRP alone[1].

[References]

[1]. Jane DE, et al. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.Neuropharmacology. 1996;35(8):1029-35.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₃NO₄

[ Molecular Weight ]:
175.18200

[ Exact Mass ]:
175.08400

[ PSA ]:
100.62000

[ LogP ]:
0.74360

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.