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FGF-401

Names

[ CAS No. ]:
1708971-55-4

[ Name ]:
FGF-401

[Synonym ]:
1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-
N-{5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl}-7-formyl-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
FGF401

Biological Activity

[Description]:

FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Research Areas >> Cancer

[Target]

FGFR4:1.9 nM (IC50)


[In Vivo]

FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma[1].

[References]

[1]. WO2015059668A1


[Related Small Molecules]

Nintedanib (BIBF 1120) | Infigratinib (BGJ398) | AZD4547 | PD173074 | Erdafitinib(JNJ-42756493) | SU 5402 | Heparan Sulfate | Lucitanib | LY2784544 | BLU554 | Dovitinib (TKI-258, CHIR-258) | Rogaratinib | LY2874455 | BLU-9931 | KW-2449

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
852.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H30N8O4

[ Molecular Weight ]:
506.557

[ Flash Point ]:
469.1±34.3 °C

[ Exact Mass ]:
506.239014

[ LogP ]:
-0.15

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.654

[ Storage condition ]:
-20℃

Related Compounds