LTX-401

LTX-401 (LTX401) is an oncolytic amino acid derivative with potential immunogenic properties, selectively destroys the structure of the Golgi apparatus; selectively enriched in the Golgi rather than in mitochondria or in the cytosol, induced all major hallmarks of immunogenic cell death detectable with biosensor cell lines including calreticulin exposure, ATP release, HMGB1 exodus and a type-1 interferon response; induces DAMP release in melanoma cells and causes complete regression of B16 melanoma.

References 1. Eike LM, et al. PLoS One. 2016 Feb 16;11(2):e0148980. 2. Zhou H, et al. Cell Death Differ. 2016 Dec;23(12):2031-2041. 3. Zhou H, et al. Cell Death Differ. 2018 Jan;25(1):227-228. View Related Products by Target Other Targets