MC-betaglucuronide-MMAE-1

Names

[ Name ]:
MC-betaglucuronide-MMAE-1

Biological Activity

[Description]:

MC-betaglucuronide-MMAE-1 is a drug-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Auristatin

[References]

[1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₆H₉₈N₈O₂₀

[ Molecular Weight ]:
1323.53

Related Compounds

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