MPPG

Names

[ Name ]:
MPPG

[Synonym ]:
mppg
MFCD00672651

Biological Activity

[Description]:

MPPG is a potent and selective L-AP4-sensitive receptor antagonist with an kD value of 9.2 μM, being tested on the neonatal rat spinal cord[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

kD: 9.2 μM (L-AP4)[1]

[References]

[1]. Jane DE, et al. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology. 1995;34(8):851-856.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₂NO₅P

[ Molecular Weight ]:
245.16900

[ Exact Mass ]:
245.04500

[ PSA ]:
130.66000

[ LogP ]:
0.44840

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Blockade of the locomotor stimulant effects of amphetamine by group I, group II, and group III metabotropic glutamate receptor ligands in the rat nucleus accumbens: possible interactions with dopamine receptors.

Neuropharmacology 44 , 717-727, (2003)

Previous investigations have shown that mGlu receptors would be involved in the amphetamine-induced motor response. However, data are somewhat controversial across studies where methodological protoco...

Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR antagonist MPPG.

Neuropharmacology 35 , 239-241, (1996)

The metabotropic glutamate receptor (mGluR) agonists CCG-I and L-AP4, acting at Group II and Group III mGluRs respectively, can reduce GABAergic synaptic inhibition on single neurones in the rat thala...

Down-regulation of mGluR8 in pilocarpine epileptic rats.

Synapse 47 , (2003)

Activation of presynaptic metabotropic glutamate receptors (mGluRs) leads to a powerful inhibition of glutamate release from many synaptic terminals throughout the CNS. mGluRs as autoreceptors are bel...

Related Compounds

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