LW479

Names

[ Name ]:
LW479

[Synonym ]:
6-{2-[2-(3-Bromophenyl)-4-oxo-1,3-thiazolidin-3-yl]phenoxy}-N-hydroxyhexanamide
Hexanamide, 6-[2-[2-(3-bromophenyl)-4-oxo-3-thiazolidinyl]phenoxy]-N-hydroxy-

Biological Activity

[Description]:

LW479, a novel HDAC inhibitor, could be a candidate drug for breast cancer prevention.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Li J, et al. Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, by down-regulating EGFR expression. Br J Pharmacol. 2015 Aug;172(15):3817-30.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₂₃BrN₂O₄S

[ Molecular Weight ]:
479.387

[ Exact Mass ]:
478.056183

[ LogP ]:
3.60

[ Index of Refraction ]:
1.628

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H400

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds

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