Alpha-Methyl-Gamma-Butyrolactone

[ Density]:
1.04g/cm3

[ Boiling Point ]:
78ºC(10 torr)

[ Molecular Formula ]:
C₅H₈O₂

[ Molecular Weight ]:
100.11600

[ Flash Point ]:
75ºC

[ Exact Mass ]:
100.05200

[ PSA ]:
26.30000

[ LogP ]:
0.56940

[ Vapour Pressure ]:
0.386mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.432(lit.)

[ Water Solubility ]:
THF: soluble

Click to get detail MSDS

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F+

[ Safety Phrases ]:
S23

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932209090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity

Bioorg. Med. Chem. 16 , 7504-9, (2008)

Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate rema...

Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function.

J. Pharmacol. Exp. Ther. 309(2) , 677-83, (2004)

Alkyl-substituted butyrolactones have both inhibitory and stimulatory effects on GABA(A) receptors. Lactones with small alkyl substitutions at the alpha-position positively modulate the channel, where...

Sites of reaction of pilocarpine.

J. Am. Soc. Mass Spectrom. 10(3) , 209-16, (1999)

Analysis of the sites of reaction of a biologically important compound, pilocarpine, a molecule with imidazole and butyrolactone rings connected by a methylene bridge, has been accomplished in a quadr...

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