5-METHOXYGRAMINE
Names
[ CAS No. ]:
16620-52-3
[ Name ]:
5-METHOXYGRAMINE
[Synonym ]:
1-(5-methoxy-1H-indol-3-yl)-N,N-dimethylmethanamine
EINECS 240-669-8
5-METHOXYGRAMINE
MFCD00005630
Chemical & Physical Properties
[ Density]:
1.119g/cm3
[ Boiling Point ]:
334.7ºC at 760 mmHg
[ Melting Point ]:
123-126 °C(lit.)
[ Molecular Formula ]:
C12H16N2O
[ Molecular Weight ]:
204.26800
[ Flash Point ]:
156.2ºC
[ Exact Mass ]:
204.12600
[ PSA ]:
28.26000
[ LogP ]:
2.23810
[ Vapour Pressure ]:
0.000126mmHg at 25°C
[ Storage condition ]:
Refrigerator (+4°C)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NL7700000
- CHEMICAL NAME :
- Indole, 3-((dimethylamino)methyl)-5-methoxy-
- CAS REGISTRY NUMBER :
- 16620-52-3
- BEILSTEIN REFERENCE NO. :
- 0170533
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C12-H16-N2-O
- MOLECULAR WEIGHT :
- 204.30
- WISWESSER LINE NOTATION :
- T56 BMJ D1N1&1 GO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 16,385,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04863
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
C: Corrosive;
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
NL7700000
[ HS Code ]:
2933990090
Synthetic Route
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Eur. J. Pharmacol. 498(1-3) , 59-69, (2004)
The effect of ligand pretreatment on human 5-hydroxytryptamine2C (5-HT2C) receptors was examined in CHO cells expressing high (CHO-1C7; 67+/-3 pmol/mg) or low (CHO-1C19; 72+/-10 fmol/mg) levels of the...
Kinetics of competitive drug action at 5-hydroxytryptamine2 receptors in isolated rabbit aorta.J. Pharmacol. Exp. Ther. 242(1) , 108-14, (1987)
The kinetics of agonist and antagonist interactions with the 5-hydroxytryptamine2 receptor were studied in the isolated rabbit aorta by following the antagonist-induced decrease in the steady-state re...