CRT-0105446

Names

[ Name ]:
CRT-0105446

Biological Activity

[Description]:

A novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=238 uM);

[References]

References 1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86. 2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13. View Related Products by Target LIM Kinase (LIMK)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₈F₃N₃O₂S

[ Molecular Weight ]:
421.438

Related Compounds

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