1661846-05-4
1661846-05-4 structure
- Name: CRT-0105446
- Chemical Name: CRT-0105446
- CAS Number: 1661846-05-4
- Molecular Formula: C20H18F3N3O2S
- Molecular Weight: 421.438
- Create Date: 2020-01-11 20:33:51
- Modify Date: 2024-01-02 17:48:48
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A novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=238 uM);
| Name | CRT-0105446 |
|---|
| Description | A novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=238 uM); |
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| References | References 1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86. 2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13. View Related Products by Target LIM Kinase (LIMK) |
| Molecular Formula | C20H18F3N3O2S |
|---|---|
| Molecular Weight | 421.438 |