CRT 0105950

Names

[ Name ]:
CRT 0105950

[Synonym ]:
Phenol, 4-[[5-[3-(2-chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]-
4-({5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-1,3-thiazol-2-yl}amino)phenol

Biological Activity

[Description]:

A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM).

[References]

References 1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86. 2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13. View Related Products by Target LIM Kinase (LIMK)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
556.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₆ClN₃OS

[ Molecular Weight ]:
393.889

[ Flash Point ]:
290.4±32.9 °C

[ Exact Mass ]:
393.070251

[ LogP ]:
4.37

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.695

Related Compounds

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