PESTAHIVIN

Names

[ Name ]:
PESTAHIVIN

[Synonym ]:
3-[(2R,5S,8S,11S,14S,17S,20S)-8,11-Diisobutyl-14-(1-methoxy-1H-indol-3-ylmethyl)-7,13,19,20-tetramethyl-5,17-bis-((R)-2-methyl-hexyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaaza-cyclohenicos-2-yl]-propionitrile

Biological Activity

[Description]:

HUN-7293 is a cell adhesion molecule inhibitor. HUN-7293 selectively inhibits the expression of three cell adhesion molecules (VCAM-1, ICAM-1 and E-selectin) (IC50=1-24 nM). HUN-7293 can be used in the study of inflammatory and autoimmune diseases characterized by overexpression of cell adhesion molecules[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

VCAM-1, ICAM-1, E-selectin[1].

[References]

[1]. Eva Pauwels, et al. Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway. Int J Mol Sci, 2021, 22(21), 12007.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₈₄N₈O₉

[ Molecular Weight ]:
977.28200

[ Exact Mass ]:
976.63600

[ PSA ]:
212.48000

[ LogP ]:
6.75178

Related Compounds

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