Loratadine Impurity 13

Names

[ Name ]:
Loratadine Impurity 13

[Synonym ]:
Loratadine N-Oxide
4-(8-Chloro-5,6-dihydro-1-oxido-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
Loratadine Impurity 13

Biological Activity

[Description]:

Loratadine n-oxide is a metabolite of Loratadine. Loratadine n-oxide shows antihistamine activity[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Stone EA, et al. Asymmetric Catalysis upon Helically Chiral Loratadine Analogues Unveils Enantiomer-Dependent Antihistamine Activity. J Am Chem Soc. 2020 Jul 22;142(29):12690-12698.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₃ClN₂O₃

[ Molecular Weight ]:
398.88300

[ Exact Mass ]:
398.14000

[ PSA ]:
55.00000

[ LogP ]:
4.85920

[ Index of Refraction ]:
1.638

Related Compounds

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