SLMP53-1

A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity.

References 1. Soares J, et al. Oncotarget. 2016 Jan 26;7(4):4326-43. View Related Products by Target MDM2-p53