1643469-17-3
1643469-17-3 structure
- Name: SLMP53-1
- Chemical Name: SLMP53‐1
- CAS Number: 1643469-17-3
- Molecular Formula: C20H18N2O2
- Molecular Weight: 318.376
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2020-01-13 19:08:11
- Modify Date: 2024-01-30 12:36:00
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A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity.
| Name | SLMP53‐1 |
|---|
| Description | A novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells; enhances p53 transcriptional activity and restores wt-like DNA binding ability to mut p53R280K; inhibits the growth of wt/mut p53-expressing tumors in xenograft mice models, without apparent toxicity. |
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| References | References 1. Soares J, et al. Oncotarget. 2016 Jan 26;7(4):4326-43. View Related Products by Target MDM2-p53 |
| Molecular Formula | C20H18N2O2 |
|---|---|
| Molecular Weight | 318.376 |