ODM-204

Names

[ CAS No. ]:
1642818-64-1

[ Name ]:
ODM-204

Biological Activity

[Description]:

ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme, with IC50s of 80 nM and 22 nM, respectively.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Others >> Androgen Receptor

[Target]

IC50: 80 nM (Androgen receptor), 22 nM (CYP17A1 enzyme)[1]

[References]

[1]. Oksala R, et al. Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17A1. J Steroid Biochem Mol Biol. 2018 Feb 10. pii: S0960-0760(18)30078-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₁F₃N₄

[ Molecular Weight ]:
374.40

Related Compounds